Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines

被引：66
|
作者：
Lamazzi, C
Léonce, S
Pfeiffer, B
Renard, P
Guillaumet, G
Rees, CW
Besson, T
机构：
[1] Univ La Rochelle, Pole Sci & Technol, Grp Chim Organ, Lab Genie Prot & Cellulaire, F-17042 La Rochelle 1, France
[2] Univ Orleans, CNRS, Inst Chim Organ & Analyt, F-45067 Orleans, France
[3] Inst Rech Servier, F-92150 Suresnes, France
[4] ADIR & Cie, F-92415 Courbevoie, France
[5] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 19期
关键词：
D O I：
10.1016/S0960-894X(00)00427-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4,5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effect of these compounds on cellular growth were measured. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2183 / 2185
页数：3
相关论文
共 50 条
  • [31] Microwave - Assisted Synthesis of a Library of Pyrrolo[1,2-c]quinazolines
    Georgescu, Emilian
    Dumitrascu, Florea
    Georgescu, Florentina
    Draghici, Constantin
    Dumitrescu, Denisa
    REVISTA DE CHIMIE, 2019, 70 (09): : 3094 - 3099
  • [32] Synthesis of furo[3,2-c]- and pyrano[3,2-c]quinolines by lanthanide triflate catalyzed imino-Diels-Alder reaction
    马云
    钱长涛
    谢美华
    孙杰
    ChineseJournalofChemistry, 2000, (03) : 377 - 383
  • [33] Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
    Lyakhova, Elena A.
    Gusyeva, Yulia A.
    Nekhoroshkova, Julia V.
    Shafran, Lev M.
    Lyakhov, Sergey A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (08) : 3305 - 3312
  • [34] Design and Synthesis of Imidazo/Benzimidazo[1,2-c]quinazoline Derivatives and Evaluation of Their Antimicrobial Activity
    Nandwana, Nitesh Kumar
    Singh, Rajnish Prakash
    Patel, Om P. S.
    Dhiman, Shiv
    Saini, Hitesh Kumar
    Jha, Prabhat N.
    Kumar, Anil
    ACS OMEGA, 2018, 3 (11): : 16338 - 16346
  • [35] SYNTHESES OF FURO[3,2-C]COUMARIN, PYRROLO[3,2-C]COUMARIN AND THIENO[3,2-C]COUMARIN
    TRKOVNIK, M
    DJUDJIC, R
    TABAKOVIC, I
    KULES, M
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1982, 14 (1-2) : 21 - 29
  • [36] NEW SYNTHESIS OF THIENO [3,2-C]PYRIDINES
    MAFFRAND, JP
    BOIGEGRAIN, R
    HETEROCYCLES, 1979, 12 (11) : 1479 - 1482
  • [37] NEW SYNTHESIS OF BENZOFURO[3,2-C]PYRIDINES
    KUCHEROVA, NF
    AKSANOVA, LA
    SHARKOVA, LM
    ZAGOREVSKII, VA
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1973, (07): : 908 - 909
  • [38] An expeditious procedure for the synthesis of fused imidazol[1,2-c]pyrimido[4′,5′:6,5]pyrano[3,2-h]quinolines
    Al-Thebeiti, MS
    AFINIDAD, 2000, 57 (487) : 211 - 216
  • [39] NEW SYNTHESIS OF THIENO[3,2-C]PYRIDINES
    MAFFRAND, JP
    FREHEL, D
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE PARTIE II-CHIMIE MOLECULAIRE ORGANIQUE ET BIOLOGIQUE, 1978, (1-2): : 48 - 54
  • [40] Synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines
    Avetisyan, A. A.
    Aleksanyan, I. L.
    Sargsyan, K. S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 43 (03) : 422 - 425
12345