Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines

被引：66
|
作者：
Lamazzi, C
Léonce, S
Pfeiffer, B
Renard, P
Guillaumet, G
Rees, CW
Besson, T
机构：
[1] Univ La Rochelle, Pole Sci & Technol, Grp Chim Organ, Lab Genie Prot & Cellulaire, F-17042 La Rochelle 1, France
[2] Univ Orleans, CNRS, Inst Chim Organ & Analyt, F-45067 Orleans, France
[3] Inst Rech Servier, F-92150 Suresnes, France
[4] ADIR & Cie, F-92415 Courbevoie, France
[5] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 19期
关键词：
D O I：
10.1016/S0960-894X(00)00427-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4,5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effect of these compounds on cellular growth were measured. (C) 2000 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2183 / 2185
页数：3
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