Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines

被引：66
|
作者：
Lamazzi, C
Léonce, S
Pfeiffer, B
Renard, P
Guillaumet, G
Rees, CW
Besson, T
机构：
[1] Univ La Rochelle, Pole Sci & Technol, Grp Chim Organ, Lab Genie Prot & Cellulaire, F-17042 La Rochelle 1, France
[2] Univ Orleans, CNRS, Inst Chim Organ & Analyt, F-45067 Orleans, France
[3] Inst Rech Servier, F-92150 Suresnes, France
[4] ADIR & Cie, F-92415 Courbevoie, France
[5] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 19期
关键词：
D O I：
10.1016/S0960-894X(00)00427-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4,5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effect of these compounds on cellular growth were measured. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2183 / 2185
页数：3
相关论文
共 50 条
  • [1] Synthesis of benzimidazo[1,2-c]quinazolines as possible bronchodilators
    Rao, ARR
    Bahekar, RH
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1999, 38 (04): : 434 - 439
  • [2] BENZIMIDAZO[1,2-C]QUINAZOLINES - A NEW CLASS OF ANTITUMOR COMPOUNDS
    BRANA, MF
    CASTELLANO, JM
    KEILHAUER, G
    MACHUCA, A
    MARTIN, Y
    REDONDO, C
    SCHLICK, E
    WALKER, N
    ANTI-CANCER DRUG DESIGN, 1994, 9 (06): : 527 - 538
  • [3] Condition-Dependent Selective Synthesis of Indolo[1,2-c]quinazolines and Indolo[3,2-c]quinolines from and Sulfoxonium Ylides
    Chen, Guang
    Cai, Xinyuan
    Zhang, Xinying
    Fan, Xuesen
    JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (15): : 9815 - 9828
  • [4] A synthesis of new Pyrrolo[3,2-c]quinolines
    Dudouit, F
    Houssin, R
    Hénichart, JP
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 38 (03) : 755 - 758
  • [5] Copper-Catalyzed One-Pot, Three-Component Synthesis of Imidazo[1,2-c]quinazolines and Benzimidazo[1,2-c]quinazolines
    Nandwana, Nitesh K.
    Bhawani
    Shinde, Vikki N.
    Kumar, Anil
    CHEMISTRYSELECT, 2021, 6 (43): : 12205 - 12208
  • [6] Novel 6-substituted benzothiazol-2-yl indolo[1,2-c]quinazolines and benzimidazo[1,2-c]quinazolines
    Frère, S
    Thiéry, V
    Bailly, C
    Besson, T
    TETRAHEDRON, 2003, 59 (06) : 773 - 779
  • [7] SYNTHESIS AND REACTIONS OF CERTAIN 6-SUBSTITUTED BENZIMIDAZO(1,2-C)QUINAZOLINES
    DAVIS, M
    MANN, FG
    JOURNAL OF THE CHEMICAL SOCIETY, 1962, (MAR): : 945 - &
  • [8] NEW METHODOLOGY FOR THE PREPARATION OF PYRROLE AND INDOLE-DERIVATIVES VIA IMINOPHOSPHORANES - SYNTHESIS OF PYRROLO[1,2-A]QUINOXALINES, INDOLO[3,2-C]QUINOLINES AND INDOLO[1,2-C]QUINAZOLINES
    MOLINA, P
    ALAJARIN, M
    VIDAL, A
    TETRAHEDRON, 1990, 46 (03) : 1063 - 1078
  • [9] Synthesis and reactions of furo[3,2-c]quinolines and furo[3,2-c]coumarins.
    Abd El-Nabi, HA
    El-din, AMN
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2003, 35 (05) : 509 - 514
  • [10] Synthesis, characterization and in vitro antifungal evaluation of novel benzimidazo[1,2-c]quinazolines
    Insuasty, B. A.
    Torres, H.
    Quiroga, J.
    Abonia, R.
    Rodriquez, R.
    Nogueras, M.
    Sanchez, A.
    Saitz, C.
    Alvarez, S. L.
    Zacchino, S. A.
    JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2006, 51 (02): : 927 - 932
12345