Immune cell biochemical abnormalities in systemic lupus erythematosus

被引：0
作者：
Liossis, SNC
Vassilopoulos, D
Kovacs, B
Tsokos, GC
机构：
[1] WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307
[2] UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV RHEUMATOL & IMMUNOL,BETHESDA,MD 20814
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1997年 / 15卷 / 06期
关键词：
SLE; T cells; B cells; signal transduction;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Novel data have emerged which attempt to characterize the biochemical abnormalities that are exhibited by lupus immune cells. Lupus lymphocytes display abnormal antigen-receptor-mediated signaling, consisting of increased Ca2+ mobilization and increased protein tyrosyl phosphorylation that are independent of disease activity. Abnormalities in the expression and function of co-stimulatory molecules (B7-CD28 and CD40-CD40L) have been established. Transcription of cytokine genes and the methylation of DNA which affects multiple genes are also abnormal. Finally, aberrations of the apoptosis of lupus immune cells are contributors to the pathogenesis of the disease.
引用
收藏
页码：677 / 684
页数：8
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