Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst

被引：66

作者：

Guo, Beibei ^{[1
]}

de Vries, Johannes G. ^{[2
]}

Otten, Edwin ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, Nijenborgh 4, NL-9747 AG Groningen, Netherlands

[2] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

CHEMICAL SCIENCE | 2019年 / 10卷 / 45期

关键词：

BOND FORMATION; TEMPLATE CATALYSIS; MICHAEL ADDITIONS; WATER ACTIVATION; COMPLEXES; HYDROLYSIS; AMINO; ACID; CO2; RU;

D O I：

10.1039/c9sc04624k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in (BuOH)-Bu-t as solvent. Reactions occur under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration is proposed that is initiated by metal-ligand cooperative binding of the nitrile.

引用

页码：10647 / 10652

页数：6

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