Rhodium-catalyzed [2+2+2] cycloaddition reactions of terminal alkynes with N-sulfonyl ketimines

被引：5
|
作者：
Zhang, Wei [1 ]
Zhang, Qian-Ru [1 ]
Dong, Lin [1 ]
机构：
[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, West China Sch Pharm, Chengdu 610041, Peoples R China
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 03期
关键词：
1,2-Dihydropyridines; Rhodium; Terminal alkynes; 2+2+2] cycloaddition; N-Sulfonyl ketimines; STEREOSELECTIVE-SYNTHESIS; AZA-NICKELACYCLE; IMINES; PYRIDINES; 1,2-DIHYDROPYRIDINES; CYCLIZATION; CHEMISTRY;
D O I：
10.1016/j.tetlet.2014.11.122
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple approach for the direct synthesis of 1,2-dihydropyridines was developed involving a one-step rhodium-catalyzed [2+2+2] cycloaddition between N-sulfonyl ketimines and two terminal alkynes. Mechanistic studies suggested a stepwise reaction of an imine and alkyne with rhodium(III), followed by the insertion of a second alkyne. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：546 / 548
页数：3
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