Dermatomyositis: Clinical features and pathogenesis

被引：276

作者：

DeWane, Madeline E. ^{[1
]}

Waldman, Reid ^{[2
]}

Lu, Jun ^{[2
]}

机构：

[1] Univ Connecticut, Sch Med, Farmington, CT USA

[2] Univ Connecticut, Dept Dermatol, 21 South Rd, Farmington, CT 06032 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2020年 / 82卷 / 02期

关键词：

amyopathic dermatomyositis; dermatomyositis; juvenile dermatomyositis; idiopathic inflammatory myopathy; interstitial lung disease; malignancy-associated dermatomyositis; Mi2; MDA5; myositis-specific antibodies; NXP2; SAE; TIF1; IDIOPATHIC INFLAMMATORY MYOPATHIES; MYOSITIS-SPECIFIC AUTOANTIBODIES; TRANSCRIPTION INTERMEDIARY FACTOR-1; CANCER-ASSOCIATED DERMATOMYOSITIS; JUVENILE DERMATOMYOSITIS; GENE; ANTI-MDA5; ANTIBODIES; JAPANESE PATIENTS; AMERICAN PATIENTS; DISEASE-ACTIVITY;

D O I：

10.1016/j.jaad.2019.06.1309

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dermatomyositis (DM) is an idiopathic inflammatory myopathy that is clinically heterogeneous and that can be difficult to diagnose. Cutaneous manifestations sometimes vary and may or may not parallel myositis and systemic involvement in time course or severity. Recent developments in our understanding of myositis-specific antibodies have the potential to change the diagnostic landscape of DM for dermatologists. Although phenotypic overlap exists, anti-Mi2, -MDA5, -NXP2, -TIF1, and -SAE antibodies may be correlated with distinct DM subtypes in terms of cutaneous manifestations, systemic involvement, and malignancy risk. This review highlights new findings on the DM-specific myositis-specific antibodies and their clinical associations in both adults and children.

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页码：267 / 281

页数：15

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