Synthesis of Phthalans Via Copper-Catalyzed Enantioselective Cyclization/Carboetherification of 2-Vinylbenzyl Alcohols

被引：26

作者：

Chen, Dake ^{[1
]}

Chemler, Sherry R. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 20期

基金：

美国国家卫生研究院;

关键词：

CARBOXYLIC-ACIDS; ALKENES; CARBOHETEROFUNCTIONALIZATION; 1,3-DIHYDROISOBENZOFURANS; FUNCTIONALIZATION; HETEROCYCLES; DERIVATIVES; FLUSPIDINE;

D O I：

10.1021/acs.orglett.8b02766

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically enriched phthalans were synthesized efficiently via an enantioselective copper-catalyzed alkene carboetherification reaction. In this reaction, 2-vinyl-benzyl alcohols enantioselectively cyclize then couple with vinylarenes. The utility of the method was demonstrated by the enantioselective synthesis of (R)-fluspidine, a sigma(1) receptor ligand.

引用

收藏

页码：6453 / 6456

页数：4

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