Nitrosamine Reactivity: A Survey of Reactions and Purge Processes

被引：22

作者：

Borths, Christopher J. ^{[4
]}

Burns, Michael ^{[1
]}

Curran, Timothy ^{[2
]}

Ide, Nathan D. ^{[3
]}

机构：

[1] Lhasa Ltd, Leeds LS11 5PS, W Yorkshire, England

[2] Vertex Pharmaceut Inc, Boston, MA 01757 USA

[3] AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA

[4] Amgen Inc, Drug Subst Technol, Cambridge, MA 02142 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2021年 / 25卷 / 08期

关键词：

nitrosamines; nitrosoamines; N-nitrosoamines; nitrosamine reactions; nitrosamine reactivity; nitrosamine purge; nitrosamine removal; impurity purge; impurity control; FISCHER-HEPP REARRANGEMENT; CYCLIC N-NITROSAMINES; NICKEL-ENHANCED IRON; FACILE DENITROSATION; GRIGNARD-REAGENTS; AQUEOUS-SOLUTION; RAPID REDUCTION; GRANULAR IRON; NITROSODIMETHYLAMINE; PHOTOLYSIS;

D O I：

10.1021/acs.oprd.1c00162

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Drug recalls have led to increased regulatory scrutiny into the formation and presence of nitrosamine (N-nitrosoamine) impurities in medicines. This review aims to assist the development of risk mitigation strategies by summarizing known reactions of nitrosamines, with a focus on reactions useful within the context of complex molecule synthesis. This review should serve as a useful reference and help lead to the development of chemical processes which effectively control nitrosamines.

引用

页码：1788 / 1801

页数：14

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