Proteomic Profiling of Signaling Networks Modulated by G-CSF/Plerixafor/Busulfan-Fludarabine Conditioning in Acute Myeloid Leukemia Patients in Remission or with Active Disease prior to Allogeneic Stem Cell Transplantation

被引：2

作者：

Zeng, Zhihong ^{[1
]}

Liu, Wenbin ^{[2
]}

Benton, Christopher B. ^{[1
]}

Konoplev, Sergej ^{[3
]}

Lu, Hongbo ^{[1
]}

Wang, Rui-Yu ^{[1
]}

Chen, Julianne ^{[4
]}

Shpall, Elizabeth ^{[4
]}

Baggerly, Keith A. ^{[2
]}

Champlin, Richard ^{[4
]}

Konopleva, Marina ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, 1515 Holcombe Blvd, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA

来源：

ACTA HAEMATOLOGICA | 2019年 / 142卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Acute myeloid leukemia; CXCR4; Proteomic profiling of signaling; Plerixafor; Allogeneic stem cell transplantation; ACUTE MYELOGENOUS LEUKEMIA; HEMATOPOIETIC STEM; PHASE; 1/2; G-CSF; CHEMOSENSITIZATION; MOBILIZATION; PLERIXAFOR; OUTCOMES;

D O I：

10.1159/000495456

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To characterize intracellular signaling in peripheral blood (PB) cells of acute myeloid leukemia (AML) patients undergoing pretransplant conditioning with CXCR4 inhibitor plerixafor, granulocyte colony-stimulating factor (G-CSF), and busulfan plus fludarabine (Bu+Flu) chemotherapy, we profiled 153 proteins in 33 functional groups using reverse phase protein array. CXCR4 inhibition mobilized AML progenitors and clonal AML cells, and this was associated with molecular markers of cell cycle progression. G-CSF/plerixafor and G-CSF/plerixafor/Bu+Flu modulated distinct signaling networks in AML blasts of patients undergoing conditioning with active disease compared to nonleukemic PB cells of patients in remission. We identified AML-specific proteins that remained aberrantly expressed after chemotherapy, representing putative chemoresistance markers in AML.

引用

页码：176 / 184

页数：9

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