Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker

被引：21

作者：

Huang, Ying-Hsien ^{[1
,2
,3
]}

Kuo, Ho-Chang ^{[1
,2
,3
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan

[2] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan

[3] Kaohsiung Chang Gung Mem Hosp, Kawasaki Dis Ctr, Kaohsiung 833, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 04期

关键词：

anemia; hepcidin; Kawasaki disease; iron deficiency; IMMUNOGLOBULIN TREATMENT FAILURE; RHEUMATOID-ARTHRITIS; IRON HOMEOSTASIS; GAMMA-GLOBULIN; INFLAMMATION; ASSOCIATION; EXPRESSION; INFECTION; DIAGNOSIS; SUSCEPTIBILITY;

D O I：

10.3390/ijms18040820

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have a more prolonged duration of active inflammation. In 2001, the discovery of a liver-derived peptide hormone known as hepcidin began revolutionizing our understanding of anemia's relation to a number of inflammatory diseases, including KD. This review focuses on hepcidin-induced iron deficiency's relation to transient hyposideremia, anemia, and disease outcomes in KD patients, and goes on to suggest possible routes of further study.

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