A highly efficient route to dehydroalanine containing peptides

被引：21
作者：
Burrage, SA
Raynham, T
Bradley, M [1 ]
机构：
[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
[2] Roche Discovery Welwyn, Welwyn Garden City AL7 3AY, Herts, England
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 18期
关键词：
D O I：
10.1016/S0040-4039(98)00258-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A routine method for the synthesis of dehydroalanine containing peptides has been developed. These residues are introduced as S-methyl cysteines which are subsequently oxidised and eliminated. The approach is compatible with both Boc and Fmoc protection strategies and can allow the introduction of a number of alpha beta unsaturated amino acids into peptides during synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：2831 / 2834
页数：4
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