The role and mechanism of allyl isothiocyanate on suppressing tumor cells proliferation and invasion of human hepatocellular cancer HepG2 cell line

被引：0

作者：

Wang, Yu ^{[1
,2
]}

Wang, Wei-Wei ^{[2
]}

Hou, Shi-Ke ^{[3
]}

机构：

[1] Tianjin Med Univ, Tianjin 300070, Peoples R China

[2] Tianjin First Cent Hosp, Dept Emergency, Tianjin 300192, Peoples R China

[3] Affiliated Hosp Logist Univ, Chinese Peoples Armed Police Forces, Inst Disaster Med & Publ Hlth, Tianjin 300162, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 03期

关键词：

AITC-hepatocellular cancer-oxidative damage;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Allyl isothiocyanate (AITC) is a class naturally compound found in Brassicaceae and some study found that it was able to reduce the incidence of cancers. To investigate the inhibitive effect and mechanism of AITC on proliferation and invasion of human hepatocellular cancer HepG2 cell line. We found AITC significantly inhibited the proliferation of HepG2 cells by inducing the apoptosis and cell cycle arrest of HepG2 cells. Further, it was found that cell adhesion and invasion was suppressed and ROS production was improved, the expression of tumor related gene such as MMP-2/9, Integrin alpha 5 beta 1, Survivin, Bcl-2, Cyclin B1, CDK1, p53, p21, caspase-3/8 was regulated. We also considered that AITC was able to inhibit proliferation and invasion of human hepatocellular cancer HepG2 cell line through inhibiting AKT/NF-kappa B pathway.

引用

页码：3389 / 3395

页数：7