Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps

被引:78
作者
Veiga-Lopez, Almudena [1 ]
Pu, Yong [1 ]
Gingrich, Jeremy [1 ,2 ]
Padmanabhan, Vasantha [3 ,4 ,5 ,6 ]
机构
[1] Michigan State Univ, Dept Anim Sci, Coll Agr & Nat Resources, E Lansing, MI 48824 USA
[2] Michigan State Univ, Dept Pharmacol & Toxicol, Coll Nat Sci, E Lansing, MI 48824 USA
[3] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[6] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
基金
美国农业部;
关键词
MESENCHYMAL STEM-CELLS; BISPHENOL-A EXPOSURE; EARLY-LIFE EXPOSURE; POLYCHLORINATED-BIPHENYLS PCBS; PRENATAL PHTHALATE EXPOSURES; INDUCED INSULIN-RESISTANCE; OBESITY-RELATED OUTCOMES; ADIPOCYTE DIFFERENTIATION; ADIPOGENIC DIFFERENTIATION; DNA METHYLATION;
D O I
10.1016/j.tem.2018.06.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Endocrine disrupting chemicals (EDCs) are compounds that are part of everyday consumer products and industrial manufacturing processes. EDCs can interfere with the endocrine system, including the adipose tissue. Accumulating evidence from epidemiological, animal, and in vitro studies demonstrates that EDCs can alter body weight, adipose tissue expansion, circulating lipid profile, and adipogenesis, with some resulting in transgenerational effects. These outcomes appear to be mediated through multiple mechanisms, from nuclear receptor binding to epigenetic modifications. A better understanding of the signaling pathways via which these EDCs contribute to an obesogenic phenotype, the interaction amongst complex mixtures of obesogenic EDCs, and the risks they pose relative to the obesity epidemic are still needed for risk assessment and development of prevention strategies.
引用
收藏
页码:607 / 625
页数:19
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