Role of T-regulatory cells in multiple sclerosis.

被引：0

作者：

Ignacio Rojas, Juan ^{[1
]}

Gonzalez, Sergio J. ^{[2
]}

Patrucco, Liliana ^{[1
]}

Cristiano, Edgardo ^{[1
]}

机构：

[1] Hosp Italiano Buenos Aires, Serv Neurol, Secc Neuroinmunol & Enfermedades Desmielinizantes, RA-1181 Buenos Aires, DF, Argentina

[2] Hosp Italiano Buenos Aires, Inst Ciencias Basicas & Med Expt, Unidad Med Mol & Genom, RA-1181 Buenos Aires, DF, Argentina

来源：

MEDICINA-BUENOS AIRES | 2010年 / 70卷 / 01期

关键词：

T-regulatory cells; demyelinating disease; multiple sclerosis; experimental autoimmune encephalomyelitis; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; TRANSCRIPTION FACTOR FOXP3; DENDRITIC CELLS; TGF-BETA; HLA-G; MEDIATED SUPPRESSION; IMMUNE-RESPONSES; CNS IMMUNITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Role of T-regulatory cells in multiple sclerosis. Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date) as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions. Based on that knowledge, T-regulatory cells have emerged as a key component of the physiopathology of autoimmune diseases including MS. This review compiles the current knowledge on the role and function of T-regulatory cells in MS, the most prevalent CNS autoimmune disease in humans.

引用

页码：79 / 86

页数：8

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