Pd(II)-Catalyzed o-C-H Acetoxylation of Phenylalanine and Ephedrine Derivatives with MeCOOOtBu/Ac2O

被引：131

作者：

Vickers, Chris J. ^{[1
]}

Mei, Tian-Sheng ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 11期

基金：

美国国家科学基金会;

关键词：

PALLADIUM(II)-MEDIATED OXIDATION; COUPLING REACTIONS; FUNCTIONALIZATION; CATALYST; BONDS; ACTIVATION; OXIDANT; PD(II); ARENES; MILD;

D O I：

10.1021/ol1007108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd(II)-catalyzed ortho C-H acetoxylation of triflate protected phenethyl- and phenpropylamines has been achieved with tert-butyl peroxyacetate as the stoichiometric oxidant and either DMF or CH3CN as the promoter. The reaction was found to tolerate a large variety of functional groups and could be combined with subsequent intramolecular amination to afford functionalized indoline derivatives.

引用

页码：2511 / 2513

页数：3

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