Prophylactic Dosing of Vitamin K to Prevent Bleeding

被引:25
作者
Witt, Mauri [1 ]
Kvist, Nina [3 ]
Jorgensen, Marianne Horby [4 ]
Hulscher, Jan B. F. [1 ]
Verkade, Henkjan J. [2 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Surg, Groningen, Netherlands
[2] Univ Groningen, Dept Pediat, Univ Med Ctr Groningen, Pediat Gastroenterol & Hepatol,Beatrix Childrens, NL-9700 AB Groningen, Netherlands
[3] Univ Copenhagen Hosp, Dept Pediat Surg, DK-2100 Copenhagen, Denmark
[4] Univ Copenhagen Hosp, Dept Pediat & Adolescent Med, DK-2100 Copenhagen, Denmark
关键词
BILIARY ATRESIA; HEMORRHAGIC-DISEASE; CHILDHOOD-CANCER; EFFICACY; EPIDEMIOLOGY;
D O I
10.1542/peds.2015-4222
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BACKGROUND AND OBJECTIVES: Based on a high incidence of Vitamin K deficiency bleeding (VKDB) in breastfed infants with thus far unrecognized cholestasis, such as biliary atresia (BA), the Dutch regimen to prevent VKDB in breastfed infants was changed from a daily oral dosage of 25 mu g to 150 mu g vitamin K. Infants continued to receive 1 mg of vitamin K orally at birth. We compared the efficacy of the 150-mu g regimen with the 25-mu g regimen and with the Danish regimen of a single intramuscular (IM) dose of 2 mg vitamin K at birth. METHODS: Data were retrieved from the national BA registries: 25 mu g group (Netherlands, January 1991 to February 2011); 150 mu g group (Netherlands, March 2011 to January 2015); and IM 2 mg group (Denmark, July 2000 to November 2014). We compared the incidence of VKDB in the groups. RESULTS: VKDB occurred in 45 of 55 (82%) infants of the 25 mu g group, in 9 of 11 (82%) of the 150 mu g group, but in only 1 of 25 (4%) of the IM 2 mg group (P<.001). Forty percent of all infants of the 25 mu g group had an intracranial hemorrhage as presenting symptom, compared with 27% of the infants of the 150 mu g group (P=.43). Intracranial hemorrhage was not observed in the IM 2 mg group (0%; P<.001). CONCLUSIONS: A vitamin K prophylactic regimen of 1 mg of vitamin K orally at birth followed by a daily oral dosage of either 25 or 150 mu g fails to prevent VKDB in breastfed infants with still unrecognized BA. The data support 2 mg vitamin K IM at birth as prophylaxis against VKDB.
引用
收藏
页数:7
相关论文
共 26 条
[1]  
[Anonymous], 2000, Cochrane Database of Systematic Reviews, DOI [10.1002/14651858.CD002776, DOI 10.1002/14651858.CD002776]
[2]  
[Anonymous], 2011, NEDERLANDS TIJDSCHRI
[3]   Epidemiology of biliary atresia in France: a national study 1986-96 [J].
Chardot, C ;
Carton, M ;
Spire-Bendelac, N ;
Le Pommelet, C ;
Golmard, JL ;
Auvert, B .
JOURNAL OF HEPATOLOGY, 1999, 31 (06) :1006-1013
[4]   Prevention of vitamin K deficiency bleeding: Efficacy of different multiple oral dose schedules of vitamin K [J].
Cornelissen, M ;
vonKries, R ;
Loughnan, P ;
Schubiger, G .
EUROPEAN JOURNAL OF PEDIATRICS, 1997, 156 (02) :126-130
[5]   FACTORS ASSOCIATED WITH CHILDHOOD-CANCER IN A NATIONAL COHORT STUDY [J].
GOLDING, J ;
PATERSON, M ;
KINLEN, LJ .
BRITISH JOURNAL OF CANCER, 1990, 62 (02) :304-308
[6]  
Hack W W, 1996, Ned Tijdschr Geneeskd, V140, P937
[7]   Weekly oral vitamin K prophylaxis in Denmark [J].
Hansen, KN ;
Minousis, M ;
Ebbesen, F .
ACTA PAEDIATRICA, 2003, 92 (07) :802-805
[8]   Biliary atresia [J].
Hartley, Jane L. ;
Davenport, Mark ;
Kelly, Deirdre A. .
LANCET, 2009, 374 (9702) :1704-1713
[9]  
Health Council of the Netherlands, 2010, HLTH COUNC NETH PUBL, V2010/11E
[10]   Incidence of late vitamin K deficiency bleeding in newborns in the Netherlands in 2005: evaluation of the current guideline [J].
IJland, Marloes M. ;
Pereira, Rob Rodrigues ;
Cornelissen, Elisabeth A. M. .
EUROPEAN JOURNAL OF PEDIATRICS, 2008, 167 (02) :165-169