A new 11,10-guaiane-type sesquiterpenoid from the roots of Stellera chamaejasme Linn

被引：5

作者：

Hu, Fei-Feng ^{[1
]}

Qi, Dan-Dan ^{[2
]}

Xu, Sha ^{[2
]}

Mao, Wei ^{[2
]}

机构：

[1] Zhejiang Drug Inspect Ctr, Hangzhou, Peoples R China

[2] Hangzhou Zhongmeihuadong Pharmaceut Co Ltd, 866 Moganshan Rd, Hangzhou 310005, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2021年 / 45卷 / 3-4期

关键词：

cytotoxic; guaiane; lignan; sesquiterpenoid; Stellera chamaejasme; AGARWOOD; GUAIANE;

D O I：

10.1177/1747519820961047

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chamaejasmone F, a new 11,10-guaiane-type sesquiterpenoid, is isolated from the roots of Stellera chamaejasme Linn., along with four known compounds including two guaiane sesquiterpenoids and two lignans. The structure of the new compound is elucidated by extensive spectroscopic analysis, especially two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The known compounds 1 beta-hydroxy-10 beta H-guaia-4,11-dien-3-one and (+)-hinokinin are isolated from the genus Stellera for the first time. In an in vitro assay, chamaejasmone F shows moderate cytotoxic activity against the human triple negative breast cancer cell line MB-MDA-231.

引用

页码：225 / 227

页数：3

共 21 条

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