Obesity-induced cognitive impairment in older adults: a microvascular perspective

被引：77

作者：

Balasubramanian, Priya ^{[1
]}

Kiss, Tamas ^{[1
,2
,3
,4
]}

Tarantini, Stefano ^{[1
,5
,6
]}

Nyul-Toth, Adam ^{[1
,7
]}

Ahire, Chetan ^{[1
]}

Yabluchanskiy, Andriy ^{[1
]}

Csipo, Tamas ^{[1
,5
,8
]}

Lipecz, Agnes ^{[1
,5
]}

Tabak, Adam ^{[5
,9
,10
]}

Institoris, Adam ^{[11
]}

Csiszar, Anna ^{[1
,2
,3
,4
]}

Ungvari, Zoltan ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,Vasc Cognit Impairment &, Reynolds Oklahoma Ctr Aging,Ctr Gerosci & Hlth Br, Oklahoma City, OK 73190 USA

[2] Univ Szeged, Theoret Med Doctoral Sch, Dept Med Phys, Int Training Program Gerosci, Szeged, Hungary

[3] Univ Szeged, Dept Informat & Cell Biol, Szeged, Hungary

[4] Univ Szeged, Dept Mol Med, Szeged, Hungary

[5] Semmelweis Univ, Doctoral Sch Basic & Translat Med, Dept Publ Hlth, Int Training Program Gerosci, Budapest, Hungary

[6] Univ Oklahoma, Hlth Sci Ctr, Hudson Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK 73104 USA

[7] Biol Res Ctr, Inst Biophys, Int Training Program Gerosci, Szeged, Hungary

[8] Univ Debrecen, Fac Med, Dept Cardiol, Div Clin Physiol,Int Training Program Gerosci, Debrecen, Hungary

[9] Semmelweis Univ, Fac Med, Dept Internal Med & Oncol, Budapest, Hungary

[10] UCL, Dept Epidemiol & Publ Hlth, London, England

[11] Univ Calgary, Cumming Sch Med, Hotchkiss Brain Inst, Dept Physiol & Pharmacol, Calgary, AB, Canada

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2021年 / 320卷 / 02期

关键词：

aging; endothelial dysfunction; metabolic syndrome; senescence; BLOOD-BRAIN-BARRIER; HIGH-FAT DIET; BODY-MASS INDEX; TERM CALORIC RESTRICTION; PHYSICAL-ACTIVITY INTERVENTION; VASCULAR OXIDATIVE STRESS; LIFE-STYLE INTERVENTION; ENDOTHELIAL-CELLS; ADIPOSE-TISSUE; RISK-FACTORS;

D O I：

10.1152/ajpheart.00736.2020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.

引用

页码：H740 / H761

页数：22

共 323 条

[91] Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells [J].