Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease

被引：15
作者：
Xiao, WenJuan [1 ]
Liu, ZeLin [2 ]
Lin, JiangHai [1 ]
Li, JingBo [1 ]
Wu, KeJing [1 ]
Ma, Yun [2 ]
Gong, YingXue [1 ]
Liu, ZeHuan [1 ]
机构：
[1] Jinan Univ, Coll Life Sci & Technol, Res Ctr Mol Biol, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Affiliated Hosp 2, Shenzhen Peoples Hosp, Shenzhen, Peoples R China
来源：
AUTOIMMUNITY | 2015年 / 48卷 / 01期
关键词：
Association; case-control study; Graves' disease; single nucleotide polymorphisms; Toll like receptor; AUTOIMMUNE THYROID-DISEASES; SINGLE-NUCLEOTIDE POLYMORPHISMS; TOLL-LIKE RECEPTORS; CLUSTER TLR10-TLR1-TLR6; LINKAGE DISEQUILIBRIUM; IMMUNE-RESPONSES; ASSOCIATION; INNATE; POPULATION; AGE;
D O I：
10.3109/08916934.2014.939269
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Graves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll-like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD in Chinese Cantonese population. Seven single nucleotide polymorphisms (i.e. rs4833095 and rs5743565 in TLR1; rs5743808 in TLR6; and rs4504265, rs11466655, rs11096957 and rs10856839 in TLR10) were evaluated in 332 GD patients and 351 unrelated controls from Chinese Cantonese population. SNP rs5743565 in TLR1 conferred a protective effect against GD. The minor allele G of rs5743565 decreased the risk of GD in all cases (odds ratio; ORG (vs.) (A) = 0.72 (0.58-0.91); p = 0.005; p(trend) = 0.004) and early onset patients (ORG (vs.) (A) = 0.72 (0.56-0.91); p = 0.007; p(trend) = 0.006). This study provided evidence that genetic variation rs5743565 in TLR1 might be associated with the decreased susceptibility of GD.
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页码：13 / 18
页数：6
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