PD-L1 expression and overall survival in Asian and western patients with gastric cancer

被引：3

作者：

Rha, Sun Young ^{[1
,2
]}

Ku, Geoffrey Y. ^{[3
]}

Kim, Hyo Song ^{[1
]}

Chung, Hyun Cheol ^{[1
,2
]}

Amlashi, Fatemeh Ghazanfari ^{[4
]}

Maru, Dipen Maheshbhai ^{[4
]}

Fein, Carly A. ^{[3
]}

Tang, Laura H. ^{[3
]}

Zhou, Wei ^{[5
]}

Wu, Ting ^{[5
]}

Peter, Senaka A. ^{[5
]}

Kelsen, David P. ^{[3
]}

Ajani, Jaffer A. ^{[4
]}

机构：

[1] Yonsei Univ Hlth Syst, Yonsei Canc Ctr, 50-1 Yonsei Ro, Seoul 03722, South Korea

[2] Yonsei Univ, Songdang Inst Canc Res, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea

[3] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA

[4] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[5] Merck & Co Inc, 126 E Lincoln Ave, Rahway, NJ 07065 USA

来源：

FUTURE ONCOLOGY | 2022年 / 18卷 / 21期

关键词：

expression; gastric cancer; overall survival; prognosis; PD-L1; LIGAND; 1; EXPRESSION; T-CELL EXCLUSION; PROGNOSTIC-SIGNIFICANCE; UNITED-STATES; EAST; HETEROGENEITY;

D O I：

10.2217/fon-2022-0103

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Data are limited on PD-L1 expression and its association with overall survival (OS) in gastric cancer (GC) patients receiving routine care in different regions. Materials & methods: In a retrospective study, PD-L1 expression was assayed using the 22C3 pharmDx on GC tumor samples collected between 2003 and 2017 at South Korean and US cancer centers. PD-L1 positivity was defined as combined positive score (CPS) >= 1. The relationship between PD-L1 and OS was analyzed. Results: Of 574 GC tumor samples, 67.4% were CPS >= 1 (68.7% in Korean and 65.7% in US patients). PD-L1 expression was not associated with OS (adjusted hazard ratio: 0.94; 95% CI: 0.75-1.17). Conclusion: PD-L1 prevalence and its association with OS was similar between South Korean and US GC patients.

引用

页码：2623 / 2634

页数：12

共 50 条

[1] Identification of Malassezia globosa as a Gastric Fungus Associated with PD-L1 Expression and Overall Survival of Patients with Gastric Cancer
Zhang, Zhenzhan
Qiu, Yaopeng
Feng, Hao
Huang, Donghua
Weng, Binshu
Xu, Zhou
Xie, Qingfeng
Wang, Zhe
Ding, Wenfu
Li, Guoxin
Liu, Hao
JOURNAL OF IMMUNOLOGY RESEARCH, 2022, 2022
[2] Association between PD-L1 Expression on Tumour-Infiltrating Lymphocytes and Overall Survival in Patients with Gastric Cancer
Fang, Wenfeng
Chen, Ying
Sheng, Jin
Zhou, Ting
Zhang, Yaxiong
Zhan, Jianhua
Liu, Lin
Huang, Jiaxing
Peng, Peijian
Zhang, Li
JOURNAL OF CANCER, 2017, 8 (09): : 1579 - 1585
[3] A gene polymorphism in PD-L1 promoter region is not associated with PD-L1 expression and patients' survival in gastric cancer
Wang, Weili
Liao, Ping
He, Yijing
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2017, 66 (10) : 1379 - 1381
[4] A gene polymorphism in PD-L1 promoter region is not associated with PD-L1 expression and patients’ survival in gastric cancer
Weili Wang
Ping Liao
Yijing He
Cancer Immunology, Immunotherapy, 2017, 66 : 1379 - 1381
[5] Expression of PD-L1 in gastric cancer
Polushkina, T.
Sotnikova, T.
Kalinin, D.
Danilova, N.
VIRCHOWS ARCHIV, 2024, 485 : S499 - S499
[6] PD-L1 is an independent prognostic predictor in gastric cancer of Western patients
Boeger, Christine
Behrens, Hans-Michael
Mathiak, Micaela
Krueger, Sandra
Kalthoff, Holger
Roecken, Christoph
ONCOTARGET, 2016, 7 (17) : 24269 - 24283
[7] Overall Survival and PD-L1 Expression in Metastasized Malignant Melanoma
Gadiot, Jules
Hooijkaas, Anna I.
Kaiser, Andrew D. M.
van Tinteren, Harm
van Boven, Hester
Blank, Christian
CANCER, 2011, 117 (10) : 2192 - 2201
[8] Overall survival and PD-L1 expression in patients with recurrent or metastatic head and neck cancer treated with nivolumab
Okamoto, Isaku
Sato, Hiroki
Tsukahara, Kiyoaki
AURIS NASUS LARYNX, 2020, 47 (04) : 676 - 686
[9] Highly Activated PD-1/PD-L1 Pathway in Gastric Cancer with PD-L1 Expression
Saito, Hiroaki
Kono, Yusuke
Murakami, Yuki
Shishido, Yuji
Kuroda, Hirohiko
Matsunaga, Tomoyuki
Fukumoto, Yoji
Osaki, Tomohiro
Ashida, Keigo
Fujiwara, Yoshiyuki
ANTICANCER RESEARCH, 2018, 38 (01) : 107 - 112
[10] PD-L1 expression in patients with metastatic gastric cancer in South Korea
Kim, Hyo Song
Wu, Ting
Kim, Hyunki
Chung, Hyun Cheol
Ajani, Jaffer A.
Ku, Geoffrey Yuyat
Kelsen, David Paul
Zhu, Xingshu
Savage, Mary J.
Koshiji, Minori
Rha, Sun Young
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35

← 1 2 3 4 5 →