Total synthesis of (±)-jiadifenin, a non-peptidyl neurotrophic modulator

被引：59

作者：

Cho, YS

Carcache, DA

Tian, Y

Li, YM

Danishefsky, SJ

机构：

[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA

[2] Sloan Kettering Inst Canc Res, Lab Biochem & Pharmacol, New York, NY 10021 USA

[3] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 44期

关键词：

D O I：

10.1021/ja045939p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1. Copyright © 2004 American Chemical Society.

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页码：14358 / 14359

页数：2

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