Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications

被引：13

作者：

Fujii, Masayuki ^{[1
]}

Sato, Toshiro ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Gastroenterol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

来源：

GENOME MEDICINE | 2017年 / 9卷

基金：

日本学术振兴会;

关键词：

COLON-CANCER; TRANSPLANTATION; GENERATION; MODELS;

D O I：

10.1186/s13073-017-0460-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5(+) intestinal stem cells, providing insights into their roles in homeostasis and cancer.

引用

页数：4

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