Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics

被引:30
作者
Byrne, Hugh J. [1 ]
Behl, Isha [2 ,3 ]
Calado, Genecy [2 ,3 ]
Ibrahim, Ola [4 ]
Toner, Mary [5 ]
Galvin, Sheila [6 ]
Healy, Claire M. [6 ]
Flint, Stephen [6 ]
Lyng, Fiona M. [2 ,3 ]
机构
[1] Technol Univ Dublin, FOCAS Res Inst, City Campus, Dublin 8, Ireland
[2] Technol Univ Dublin, Sch Phys & Clin & Optometr Sci, City Campus, Dublin 8, Ireland
[3] Technol Univ Dublin, FOCAS Res Inst, Radiat & Environm Sci Ctr, City Campus, Dublin 8, Ireland
[4] Trinity Coll Dublin, Sch Dent Sci, Lincoln Pl, Dublin 2, Ireland
[5] St James Hosp, Cent Pathol Lab, James St, Dublin 8, Ireland
[6] Trinity Coll Dublin, Dublin Dent Univ Hosp, Oral Med Unit, Lincoln Pl, Dublin 2, Ireland
基金
爱尔兰科学基金会;
关键词
Vibrational spectroscopy; Raman spectroscopy; Infrared spectroscopy; Oral cancer; Oral pre-cancer; Premalignant lesions; Potentially malignant lesions disease diagnostics; SQUAMOUS-CELL CARCINOMA; 2-DIMENSIONAL ELECTROPHORESIS GELS; VIVO RAMAN-SPECTROSCOPY; SPECTRAL CYTOPATHOLOGY; SALIVARY BIOMARKERS; IMPROVED PROTOCOLS; BUCCAL MUCOSA; TISSUE; DISCRIMINATION; HISTOPATHOLOGY;
D O I
10.1016/j.saa.2021.119470
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed. (C) 2021 Elsevier B.V. All rights reserved.
引用
收藏
页数:12
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