Enantioselective organocatalytic double Michael addition reactions

被引：143
作者：
Li, Hao [1 ]
Zu, Liansuo [1 ]
Xie, Hexin [1 ]
Wang, Jian [1 ]
Jiang, Wei [1 ]
Wang, Wei [1 ]
机构：
[1] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 09期
关键词：
D O I：
10.1021/ol070581y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A novel organocatalytic, enantioselective domino double Michael addition reaction of alpha,beta-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.
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收藏
页码：1833 / 1835
页数：3
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