Pathogenesis of type 2 diabetes mellitus

被引：859

作者：

DeFronzo, RA ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Diabet Div, San Antonio, TX 78229 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2004年 / 88卷 / 04期

关键词：

D O I：

10.1016/j.mcna.2004.04.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article provides an overview of the pathogenesis of type 2 diabetes mellitus. Discussion begins by describing normal glucose homeostasis and ingestion of a typical meal and then discusses glucose homeostasis in diabetes. Topics covered include insulin secretion in type 2 diabetes mellitus and insulin resistance, the site of insulin resistance, the interaction between insulin sensitivity and secretion, the role of adipocytes in the pathogenesis of type 2 diabetes, cellular mechanisms of insulin resistance including glucose transport and phosphorylation, glycogen and synthesis, glucose and oxidation, glycolysis, and insulin signaling.

引用

页码：787 / +

页数：50

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