Pathogenesis of type 2 diabetes mellitus

被引：839
作者：
DeFronzo, RA [1 ]
机构：
[1] Univ Texas, Hlth Sci Ctr, Diabet Div, San Antonio, TX 78229 USA
来源：
MEDICAL CLINICS OF NORTH AMERICA | 2004年 / 88卷 / 04期
关键词：
D O I：
10.1016/j.mcna.2004.04.013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article provides an overview of the pathogenesis of type 2 diabetes mellitus. Discussion begins by describing normal glucose homeostasis and ingestion of a typical meal and then discusses glucose homeostasis in diabetes. Topics covered include insulin secretion in type 2 diabetes mellitus and insulin resistance, the site of insulin resistance, the interaction between insulin sensitivity and secretion, the role of adipocytes in the pathogenesis of type 2 diabetes, cellular mechanisms of insulin resistance including glucose transport and phosphorylation, glycogen and synthesis, glucose and oxidation, glycolysis, and insulin signaling.
引用
收藏
页码：787 / +
页数：50
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