Synthesis and cytotoxicity of novel fatty acid-nucleoside conjugates

被引：9
|
作者：
Zhang, Yun-Xiao [1 ]
Dai, Gui-Fu [1 ]
Wang, Le [1 ]
Tao, Jing-Chao [1 ]
机构：
[1] Zhengzhou Univ, New Drug Res & Dev Ctr, Dept Chem, Zhengzhou 450052, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 06期
关键词：
tegafur; fatty acid; conjugates; synthesis; cytotoxicity;
D O I：
10.1016/j.bmcl.2006.12.092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N3-Hydroxyethyltegafur (3) was synthesized in 91.0% yield under a new condition. A series of novel fatty acid esters of 3 were synthesized. These fatty acid-nucleoside conjugates have shown cytotoxicities against Ec9706 cells and A549 cells, and the structure activity relationship was discussed. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1613 / 1615
页数：3
相关论文
共 50 条
  • [21] Triphenylphosphonium conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis and cytotoxicity evaluation
    Irina Yu. Strobykina
    Olga V. Andreeva
    Mayya G. Belenok
    Marina N. Semenova
    Victor V. Semenov
    Roman N. Chuprov-Netochin
    Anastasiya S. Sapunova
    Alexandra D. Voloshina
    Alexey B. Dobrynin
    Vyacheslav E. Semenov
    Vladimir E. Kataev
    Medicinal Chemistry Research, 2020, 29 : 2203 - 2217
  • [22] Synthesis, susceptibility to enzymatic phosphorylation, cytotoxicity and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates
    Bialek-Pietras, Magdalena
    Olejniczak, Agnieszka B.
    Paradowska, Edyta
    Studzinska, Miroslawa
    Jablonska, Agnieszka
    Lesnikowski, Zbigniew J.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2018, 865 : 166 - 172
  • [23] New phenstatin-fatty acid conjugates: Synthesis and evaluation
    Chen, Jinhui
    Brown, David P.
    Wang, Yi-Jun
    Chen, Zhe-Sheng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (18) : 5119 - 5122
  • [24] Triphenylphosphonium conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis and cytotoxicity evaluation
    Strobykina, Irina Yu.
    Andreeva, Olga V.
    Belenok, Mayya G.
    Semenova, Marina N.
    Semenov, Victor V.
    Chuprov-Netochin, Roman N.
    Sapunova, Anastasiya S.
    Voloshina, Alexandra D.
    Dobrynin, Alexey B.
    Semenov, Vyacheslav E.
    Kataev, Vladimir E.
    MEDICINAL CHEMISTRY RESEARCH, 2020, 29 (12) : 2203 - 2217
  • [25] Synthesis and Antineoplastic Efficacy of Anthraquinone and Saturated Fatty Acid Conjugates
    Mishra, Bijayashree
    Acharya, Pratap Chandra
    De, Utpal Chandra
    CHEMISTRYSELECT, 2023, 8 (25):
  • [26] SYNTHESIS AND CYTOTOXICITY STUDIES OF NOVEL CYCLIC PEPTIDE-2,6-DIMETHOXYHYDROQUINONE-3-MERCAPTOACETIC ACID CONJUGATES
    SHEH, LU
    DAI, HY
    KUAN, YH
    LI, CJ
    CHIANG, CD
    CHENG, V
    ANTI-CANCER DRUG DESIGN, 1993, 8 (03): : 237 - 247
  • [27] Fatty acid bile acid conjugates - novel agents for prevention and treatment of gallstones
    Konikoff, FM
    Frenkel, A
    Gilat, T
    GALLSTONES: PATHOGENESIS AND TREATMENT, 2004, 139 : 157 - 161
  • [28] Synthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activity
    Sanabria-Rios, David J.
    Rivera-Torres, Yaritza
    Rosario, Joshua
    Rios, Camille
    Gutierrez, Ricardo
    Carballeira, Nestor M.
    Velez, Christian
    Zayas, Beatriz
    Alvarez-Colon, Felix
    Ortiz-Soto, Gabriela
    Serrano, Victor
    Altieri-Rivera, Joanne
    Rios-Olivares, Eddy
    Rodriguez, Jose W.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (10) : 2174 - 2180
  • [29] Novel synthesis of bis(phosphonic acid)-steroid conjugates
    Page, PCB
    McKenzie, MJ
    Gallagher, JA
    JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (11): : 3704 - 3708
  • [30] Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity
    Tauchman, Jiri
    Suess-Fink, Georg
    Stepnicka, Petr
    Zava, Oliver
    Dyson, Paul J.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2013, 723 : 233 - 238
12345