Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response

被引：51

作者：

Khan, Israr ^{[1
,2
,3
,4
]}

Wei, Junshu ^{[1
,2
,3
,4
]}

Li, Anping ^{[5
]}

Liu, Zhirong ^{[5
]}

Yang, Pingrong ^{[5
]}

Jing, Yaping ^{[1
,2
,3
,4
]}

Chen, Xinjun ^{[1
,2
,3
,4
]}

Zhao, Tang ^{[1
,2
,3
,4
]}

Bai, Yanrui ^{[1
,2
,3
,4
]}

Zha, Lajia ^{[1
,2
,3
,4
]}

Li, Chenhui ^{[1
,2
,3
,4
]}

Ullah, Naeem ^{[1
,2
,3
,4
]}

Che, Tuanjie ^{[4
]}

Zhang, Chunjiang ^{[1
,2
,3
,4
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Key Lab Cell Act & Stress Adaptat, Minist Educ, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Gansu Key Lab Biomonitoring & Bioremediat Environ, Lanzhou 730000, Peoples R China

[4] Gansu Key Lab Funct Genom & Mol Diag, Lanzhou 730000, Peoples R China

[5] Gansu Inst Drug Control, Lanzhou 730030, Peoples R China

来源：

INTERNATIONAL MICROBIOLOGY | 2022年 / 25卷 / 03期

关键词：

DSS Colitis; Dysbiosis; Gut microbiota; Lactobacillus plantarum; Probiotics; SCFAs; INFLAMMATORY-BOWEL-DISEASE; CHAIN FATTY-ACIDS; FECAL MICROBIOTA; ULCERATIVE-COLITIS; INTESTINAL MICROBIOTA; CROHNS-DISEASE; PROBIOTICS; BACTERIA; CELLS; CYTOKINES;

D O I：

10.1007/s10123-022-00243-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gut microbiota has become a new therapeutic target in the treatment of inflammatory Bowel Disease (IBD). Probiotics are known for their beneficial effects and have shown good efficacy in the clinical treatment of IBD and animal models of colitis. However, how these probiotics contribute to the amelioration of IBD is largely unknown. In the current study, the DSS-induced mouse colitis model was treated with oral administration of Lactobacillus plantarum strains to investigate their effects on colitis. The results indicated that the L. plantarum strains improved dysbiosis and enhanced the abundance of beneficial bacteria related to short-chain fatty acids (SCFAs) production. Moreover, L. plantarum strains decreased the level of pro-inflammatory cytokines, i.e., IL-17A, IL-17F, IL-6, IL-22, and TNF-alpha and increased the level of anti-inflammatory cytokines, i.e., TGF-beta, IL-10. Our result suggests that L. plantarum strains possess probiotic effects and can ameliorate DSS colitis in mice by modulating the resident gut microbiota and immune response.

引用

页码：587 / 603

页数：17

共 113 条

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