Comparison of 50 μg and 25 μg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing transurethral resection of the prostate with intrathecal anesthesia

Study Objective: To compare the efficacy of 50 mu g and 25 mu g closes of intrathecal morphine on postoperative pain in patients undergoing transurethral resection of the prostate (TURP) with low-close bupivacaine Design: Randomized, double-blinded study Setting: Konya Hospital Patients: 70 ASA physical status I. II, and III patients Interventions: Patients were randomized to two groups Group A patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 50 mu g of morphine (0 5 mL) Group B patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 25 mu g of morphine (0 5 mL) Measurements: Postoperative pain scores, patient and surgeon satisfaction, and side effects such as emesis, pruritus, and respiratory depression, were recorded. Main Results: Postoperative pain characteristics were similar between the two groups Frequency of emesis was similar between the groups, while pruritus was significantly higher in Group A No antipruritic medication was required in any patient Patient and surgeon satisfaction was evaluated as good or excellent in both groups. Conclusions: Intrathecal morphine at a dose of 25 mu g provides similar postoperative analgesia and less pruritus than the 50 mu g dose in patients undergoing TURP (C) 2010 Elsevier Inc All rights reserved