Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

被引：3

作者：

El-Shamy, Ibrahim E. ^{[1
]}

Abdel-Mohsen, A. M. ^{[2
,4
]}

Fouda, Moustafa M. G. ^{[3
]}

Al-Deyab, Salem S. ^{[3
]}

El-Hashash, Maher A. ^{[5
]}

机构：

[1] Fayoum Univ, Fac Sci, Dept Chem, Al Fayyum, Egypt

[2] Brno Univ Technol, Cent European Inst Technol, CS-61090 Brno, Czech Republic

[3] King Saud Univ, Coll Sci, Dept Chem, Petrochem Res Chair, Riyadh 11451, Saudi Arabia

[4] Natl Res Ctr, Text Res Div, Giza 12522, Egypt

[5] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 14期

关键词：

C-nucleosides; Phthalazine derivatives; Biological activity; SELECTIVE PDE4 INHIBITORS; PHTHALAZINE DERIVATIVES; POTENT INHIBITORS; ANALOGS; PHOSPHODIESTERASE; IDENTIFICATION; ACID; CYCLIZATION; CHEMISTRY; LIGANDS;

D O I：

10.14233/ajchem.2014.16756

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1-Chloro-4-(2,4,6-trimethylphenyl) phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using H-1 NMR, C-13 NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

引用

页码：4405 / 4415

页数：11

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