Appel Reaction of Carboxylic Acids with Tribromoisocyanuric Acid/Triphenylphosphine: a Mild and Acid-Free Preparation of Esters and Amides

被引：9

作者：

Sindra, Haryadylla da Cunha ^{[1
]}

de Mattos, Marcio C. S. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Dept Quim Organ, Inst Quim, CP 68545, BR-21945970 Rio De Janeiro, RJ, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2016年 / 27卷 / 06期

关键词：

amides; esters; tribromoisocyanuric acid; acylation; triphenylphosphine; TRICHLOROISOCYANURIC ACID; REGIOSELECTIVE COIODINATION; TRIIODOISOCYANURIC ACID; FREE ESTERIFICATION; ALCOHOLS; REAGENT; TRIPHENYLPHOSPHINE; CONVERSION; CHLORIDES; BROMIDES;

D O I：

10.5935/0103-5053.20160006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and efficient method for esterification and amidation of carboxylic acids under neutral conditions has been developed. Esters and amides can be prepared by reacting a carboxylic acid (1 mmol) with tribromoisocyanuric acid (0.37 mmol) and triphenylphosphine (1 mmol) in dichloromethane at room temperature, followed by addition of an alcohol or an amine, respectively.

引用

收藏

页码：1129 / 1136

页数：8

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