Thermographic selection of effective catalysts from an encoded polymer-bound library

被引：265
作者：
Taylor, SJ [1 ]
Morken, JP [1 ]
机构：
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
来源：
SCIENCE | 1998年 / 280卷 / 5361期
关键词：
D O I：
10.1126/science.280.5361.267
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A general method is introduced for the rapid and simultaneous evaluation of each member of large encoded catalyst libraries for the ability to catalyze a reaction in solution. The procedure was used to select active catalysts from a library of potential polymer-bound multifunctional catalysts, From similar to 7000 beads screened (3150 distinct catalysts), 23 beads were selected for catalysis of an acylation reaction. Kinetic experiments indicate that the most strongly selected beads are also the most efficient catalysts.
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页码：267 / 270
页数：4
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