Crohn's disease (CD) is a chronic inflammatory disorder which may involve any part of gastrointestinal tract. Chronic inflammation is primarily due to an immunological imbalance between pro- and anti -inflammatory cytokines, and with a defective apoptosis of lamina propria T cells. Amongst the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) seems to play a central role in pathogenesis of CD. Over the last years, increasing knowledge on the pathogenesis of CD together with progresses in bio-technology have led to the development of a number of biological agents targeting specific molecules involved in gut inflammation, most importantly TNF-alpha and its receptors. The aim of this paper is to critically review the rationale and state-of-the art for the use TNF-alpha inhibitors in the treatment of CD.
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Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands
ten Hove, T
van Montfrans, C
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Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands
van Montfrans, C
Peppelenbosch, MP
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Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands
Peppelenbosch, MP
van Deventer, SJH
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Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands
机构:
Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands
ten Hove, T
van Montfrans, C
论文数: 0引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands
van Montfrans, C
Peppelenbosch, MP
论文数: 0引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands
Peppelenbosch, MP
van Deventer, SJH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, NetherlandsUniv Amsterdam, Acad Med Ctr, Dept Expt Internal Med G2 105, NL-1105 AZ Amsterdam, Netherlands