Application of computed tomography images in the evaluation of magnetic nanoparticles biodistribution

被引：4

作者：

Dias, Argleydson Leao ^{[2
]}

Kunzel, Roseli ^{[1
]}

Levenhagen, Ronaldo Savarino ^{[3
]}

Okuno, Emico ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Fis, BR-05508900 Sao Paulo, Brazil

[2] Ctr Univ Franciscano, Area Ciencias Tecnol, BR-97010032 Santa Maria, RS, Brazil

[3] Univ Fed Sao Paulo, BR-09941510 Diadema, SP, Brazil

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2010年 / 322卷 / 16期

关键词：

Magnetic nanoparticle; Computed tomography; Imaging contrast; Iodine;

D O I：

10.1016/j.jmmm.2010.02.046

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this work we evaluate the effectiveness of computed tomography images as a tool to determine magnetic nanoparticle biodistribution over biological tissues. For this purpose, tomography images for magnetic nanoparticles, composed of Fe(3)O(4), coated with 2,3-dimercaptosuccinic acid (DMSA), were generated at several material concentrations. The comparison of CT numbers, calculated from these images generated at clinical conditions, with typical CT numbers for biological tissues, shows that the detection of nanoparticle in most tissues is only possible for high material concentrations. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：2405 / 2407

页数：3

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