Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones

被引：93

作者：

Shaterian, Hamid Reza ^{[1
]}

Oveisi, Ali Reza ^{[1
]}

Honarmand, Moones ^{[1
]}

机构：

[1] Univ Sistan & Baluchestan, Dept Chem, Fac Sci, Zahedan, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 08期

关键词：

Al(H2PO4)3; 3-(2'benzothiazolo)-2; 3-dihydroqunazoline-4(1H)-ones; isatoic anhydride; solvent-free; ENVIRONMENTALLY FRIENDLY PREPARATION; PERCHLORIC-ACID HCLO4-SIO2; SILICA SULFURIC-ACID; ONE-POT; AMIDOALKYL NAPHTHOLS; REUSABLE CATALYST; SOLVENT-FREE; QUINAZOLINONE DERIVATIVES; TUBULIN POLYMERIZATION; HETEROGENEOUS CATALYST;

D O I：

10.1080/00397910903064831

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, inexpensive, and heterogeneous catalyst, [Al(H2PO4)3], was applied in a three-component, one-pot cyclocondensation reaction of isatoic anhydride with primary amines (or ammonium salts) and aldehydes to afford the corresponding quinazolinone derivatives in excellent yields. Reactions occurred under thermal solvent-free conditions. It was found that this solid acidic catalyst could be easily recovered and reused for at least three cycles without any loss of activity.

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页码：1231 / 1242

页数：12

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