Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development

被引：176

作者：

Kawabe, Hiroshi ^{[1
]}

Neeb, Antje ^{[1
]}

Dimova, Kalina ^{[1
,2
,3
]}

Young, Samuel M., Jr. ^{[4
]}

Takeda, Michiko ^{[1
]}

Katsurabayashi, Shutaro ^{[4
]}

Mitkovski, Miso ^{[5
]}

Malakhova, Oxana A. ^{[6
]}

Zhang, Dong-Er ^{[6
,7
,8
]}

Ulmilkawa, Masato ^{[9
]}

Kariya, Ken-ichi ^{[9
]}

Goebbels, Sandra ^{[10
]}

Nave, Klaus-Armin ^{[10
]}

Rosenmund, Christian ^{[4
]}

Jahn, Olaf ^{[2
,3
]}

Rhee, JeongSeop ^{[1
,4
]}

Brose, Nils ^{[1
]}

机构：

[1] Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany

[2] Max Planck Inst Expt Med, Prote Grp, D-37075 Gottingen, Germany

[3] DFG CMPB, D-37075 Gottingen, Germany

[4] Max Planck Inst Biophys Chem, Dept Membrane Biophys, D-37077 Gottingen, Germany

[5] Max Planck Inst Expt Med, Imaging Facil, D-37075 Gottingen, Germany

[6] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[7] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Div Biol, La Jolla, CA 92093 USA

[9] Univ Ryukyus, Div Cell Biol, Grad Sch Med, Nishihara, Okinawa 9030215, Japan

[10] Max Planck Inst Expt Med, Dept Neurogenet, D-37075 Gottingen, Germany

来源：

NEURON | 2010年 / 65卷 / 03期

基金：

日本学术振兴会; 美国国家卫生研究院;

关键词：

NUCLEOTIDE EXCHANGE FACTOR; SYNAPSE ELIMINATION; HIPPOCAMPAL-NEURONS; PUTATIVE EFFECTOR; PYRAMIDAL NEURONS; ANGELMAN SYNDROME; CORTICAL-NEURONS; PROTEIN-KINASE; WW DOMAINS; PHOSPHORYLATION;

D O I：

10.1016/j.neuron.2010.01.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nedd4-1 is a "neuronal precursor cell expressed and developmentally downregulated protein" and among the most abundant E3 ubiquitin ligases in mammalian neurons. In analyses of conventional and conditional Nedd4-1-deficient mice, we found that Nedd4-1 plays a critical role in dendrite formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A. Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the activity of Rap2 effector kinases of the TNIK family and promotes dendrite growth. We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons.

引用

页码：358 / 372

页数：15

共 61 条

[1] Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination [J].

Arévalo, Juan Carlos ;

Waite, Janelle ;

Rajagopal, Rithwick ;

Beyna, Mercedes ;

Chen, Zhe-Yu ;

Lee, Francis S. ;

Chao, Moses V. .

NEURON, 2006, 50 (04) :549-559

[2] LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons [J].

Barnes, Anthony P. ;

Lilley, Brendan N. ;

Pan, Y. Albert ;

Plummer, Lisa J. ;

Powell, Ashton W. ;

Raines, Alexander N. ;

Sanes, Joshua R. ;

Polleux, Franck .

CELL, 2007, 129 (03) :549-563

[3] EXCITATORY AND INHIBITORY AUTAPTIC CURRENTS IN ISOLATED HIPPOCAMPAL-NEURONS MAINTAINED IN CELL-CULTURE [J].

BEKKERS, JM ;

STEVENS, CF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7834-7838

[4] The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons [J].

Bloom, A. Joseph ;

Miller, Bradley R. ;

Sanes, Joshua R. ;

DiAntonio, Aaron .

GENES & DEVELOPMENT, 2007, 21 (20) :2593-2606

[5] Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling [J].

Cao, Xiao R. ;

Lill, Nancy L. ;

Boase, Natasha ;

Shi, Peijun P. ;

Croucher, David R. ;

Shan, Hongbo ;

Qu, Jing ;

Sweezer, Eileen M. ;

Place, Trenton ;

Kirby, Patricia A. ;

Daly, Roger J. ;

Kumar, Sharad ;

Yang, Baoli .

SCIENCE SIGNALING, 2008, 1 (38)

[6] Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTP gamma S [J].

Cherfils, J ;

Menetrey, J ;

LeBras, G ;

JanoueixLerosey, I ;

deGunzburg, J ;

Garel, JR ;

Auzat, I .

EMBO JOURNAL, 1997, 16 (18) :5582-5591

[7] Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development [J].

Dan, I ;

Watanabe, NM ;

Kobayashi, T ;

Yamashita-Suzuki, K ;

Fukagaya, Y ;

Kajikawa, E ;

Kimura, WK ;

Nakashima, TM ;

Matsumoto, K ;

Ninomiya-Tsuji, J ;

Kusumi, A .

FEBS LETTERS, 2000, 469 (01) :19-23

[8] Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain [J].

DiFiglia, M ;

Sapp, E ;

Chase, KO ;

Davies, SW ;

Bates, GP ;

Vonsattel, JP ;

Aronin, N .

SCIENCE, 1997, 277 (5334) :1990-1993

[9] Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo [J].

Dittgen, T ;

Nimmerjahn, A ;

Komai, S ;

Licznerski, P ;

Waters, J ;

Margrie, TW ;

Helmchen, F ;

Denk, W ;

Brecht, M ;

Osten, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (52) :18206-18211

[10] Functional regions of the presynaptic cytomatrix protein Bassoon: significance for synaptic targeting and cytomatrix anchoring [J].

Dresbach, T ;

Hempelmann, A ;

Spilker, C ;

Dieck, ST ;

Altrock, WD ;

Zuschratter, W ;

Garner, CC ;

Gundelfinger, ED .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 23 (02) :279-291

← 1 2 3 4 5 6 7 →