Substrate-Controlled and Organocatalytic Asymmetric Synthesis of Carbocyclic Amino Acid Dipeptide Mimetics

被引：24
作者：
Hanessian, Stephen [1 ]
Maji, Dilip K. [1 ]
Govindan, Subramaniyan [1 ]
Matera, Riccardo [1 ]
Tintelnot-Blomley, Marina [2 ]
机构：
[1] Univ Montreal, Dept Chem, Stn Ctr Ville, Montreal, PQ H3C 3J7, Canada
[2] Novartis Pharma AG, CH-4002 Basel, Switzerland
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 09期
基金：
加拿大自然科学与工程研究理事会;
关键词：
INTERNAL 1,2-ASYMMETRIC INDUCTION; ASPARTIC PROTEASE INHIBITORS; BETA-SECRETASE; STEREOSELECTIVE-SYNTHESIS; CONJUGATE ADDITION; ALZHEIMERS-DISEASE; HYDROXYETHYLENE ISOSTERES; MICHAEL ADDITION; ACYCLIC SYSTEMS; NITROALKANES;
D O I：
10.1021/jo100017t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric synthesis of a carbocyclic delta-amino acid representing the P-2/P-3 subunit of a nonpeptidic truncated peptidomimetic molecule is described relying on two independent approaches.
引用
收藏
页码：2861 / 2876
页数：16
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