Aurora-A amplification associated with BRCA2 mutation in breast tumours

被引：27
作者：
Bodvarsdottir, Sigridur K.
Hilmarsdottir, Holmfridur
Birgisdottir, Valgerdur
Steinarsdottir, Margret
Jonasson, Jon G.
Eyfjord, Jorunn E.
机构：
[1] Iceland Canc Soc, IS-105 Reykjavik, Iceland
[2] Univ Iceland, Dept Med, Reykjavik, Iceland
[3] Landspital Univ Hosp, IS-101 Reykjavik, Iceland
来源：
CANCER LETTERS | 2007年 / 248卷 / 01期
关键词：
breast cancer; Aurora-A; BRCA2; TP53; FISH;
D O I：
10.1016/j.canlet.2006.06.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n = 20) and non-carriers (n = 41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p = 0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p = 0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：96 / 102
页数：7
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