APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells

被引：18
作者：
Li, Shuran [1 ]
Bao, Xueyang [1 ]
Wang, Duowei [1 ]
You, Linjun [1 ]
Li, Xianjing [1 ]
Yang, Hongbao [1 ]
Bian, Jinsong [2 ]
Wang, Yun [1 ]
Yang, Yong [1 ]
机构：
[1] China Pharmaceut Univ, Ctr New Drug Safety Evaluat & Res, Jiangsu Key Lab Drug Discovery Metab Dis, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117597, Singapore
来源：
SCIENCE CHINA-LIFE SCIENCES | 2017年 / 60卷 / 06期
基金：
中国国家自然科学基金;
关键词：
APOBEC3B; interleukin-6; hepatitis; hepatocellular carcinoma; HuR; MESSENGER-RNA; TNF-ALPHA; EXPRESSION; DNA; DEAMINATION; PROGRESSION; STABILITY; PROTEINS; PATTERNS; MUTATION;
D O I：
10.1007/s11427-016-9058-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma (HCC) and APOBEC3B (A3B) remains unknown. It has been confirmed that interleukin-6 (IL-6) has significant impacts on oncogenesis of HCC. Here, we reported that the expression of IL-6 was substantially up-regulated by A3B in HepG2 cells. A3B induced IL-6 expression through relocating HuR to enhance the IL-6 mRNA stability. Further analysis indicated that IL-6 also increased the expression of A3B through JAK1/STAT3 signaling pathway, which formed a positive feedback to maintain the continuous expression of A3B and IL-6, and thereby promoted the prolonged non-resolving inflammation. Collectively, these findings suggest that A3B is essential for oncogenesis of HCC, and is a potential target for preventive intervention.
引用
收藏
页码：617 / 626
页数：10
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