Developmental aspects of language processing: fMRI of verbal fluency in children and adults

被引:184
作者
Gaillard, WD
Sachs, BC
Whitnah, JR
Ahmad, Z
Balsamo, LM
Petrella, JR
Braniecki, SH
McKinney, CM
Hunter, K
Xu, B
Grandin, CB
机构
[1] George Washington Univ, Childrens Natl Med Ctr, Dept Neurol, Sch Med, Washington, DC 20010 USA
[2] NINDS, Clin Epilepsy Sect, NIH, Bethesda, MD 20892 USA
[3] Duke Med Ctr, Dept Radiol, Durham, NC USA
[4] Catholic Univ Louvain, St Luc Univ Hosp, Dept Radiol, Brussels, Belgium
关键词
fMRI; language; verbal fluency; children; development;
D O I
10.1002/hbm.10091
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We examined developmental differences, in location and extent of fiviRI language activation maps, between adults and children while performing a semantic fluency task. We studied 29 adults and 16 children with echo planar imaging BOLD fMRI at 1.5 T using covert semantic verbal fluency (generation of words to categories compared to rest) using a block design. Post task testing was administered to assess performance. Individual data were analyzed with an a priori region of interest approach from t maps (t = 4) and asymmetry indices (AI). Group studies were analyzed using SPM 99 (Wellcome, UK; fixed effect, corrected P < 0.0001). We found no significant differences in location or laterality of activation between adults and children for a semantic verbal fluency task. Adults activated more pixels than children in left inferior frontal gyrus and left middle frontal gyrus, but AIs were the similar across ages (r(2) < 0.09). Extent or laterahty of activation was not affected by performance (r(2) < 0.15). The brain areas that process semantic verbal fluency are similar in children and adults. The laterality of activation does not change appreciably with age and appears to be strongly lateralized by age 7 years. Hum. Brain Mapping 18:176-185,2003. Published 2003 Wiley-Liss, Inc.
引用
收藏
页码:176 / 185
页数:10
相关论文
共 66 条
[1]   Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation [J].
Bahn, MM ;
Lin, WL ;
Silbergeld, DL ;
Miller, JW ;
Kuppusamy, K ;
Cook, RJ ;
Hammer, G ;
Wetzel, R ;
Cross, D .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1997, 169 (02) :575-579
[2]   A functional magnetic resonance Imaging study of left hemisphere language dominance in children [J].
Balsamo, LM ;
Xu, B ;
Grandin, CB ;
Petrella, JR ;
Braniecki, SH ;
Elliott, TK ;
Gaillard, WD .
ARCHIVES OF NEUROLOGY, 2002, 59 (07) :1168-1174
[3]   Language dominance determined by whole brain functional MRI in patients with brain lesions [J].
Benson, RR ;
FitzGerald, DB ;
LeSueur, LL ;
Kennedy, DN ;
Kwong, KK ;
Buchbinder, BR ;
Davis, TL ;
Weisskoff, RM ;
Talavage, TM ;
Logan, WJ ;
Cosgrove, GR ;
Belliveau, JW ;
Rosen, BR .
NEUROLOGY, 1999, 52 (04) :798-809
[4]   Determination of language dominance using functional MRI: A comparison with the Wada test [J].
Binder, JR ;
Swanson, SJ ;
Hammeke, TA ;
Morris, GL ;
Mueller, WM ;
Fischer, M ;
Benbadis, S ;
Frost, JA ;
Rao, SM ;
Haughton, VM .
NEUROLOGY, 1996, 46 (04) :978-984
[5]  
Boatman D, 1999, ANN NEUROL, V46, P579, DOI 10.1002/1531-8249(199910)46:4<579::AID-ANA5>3.0.CO
[6]  
2-K
[7]  
Bookheimer SY, 2000, MENT RETARD DEV D R, V6, P161, DOI 10.1002/1098-2779(2000)6:3<161::AID-MRDD2>3.3.CO
[8]  
2-N
[9]   Developmental and lesion effects in brain activation during sentence comprehension and mental rotation [J].
Booth, JR ;
MacWhinney, B ;
Thulborn, KR ;
Sacco, K ;
Voyvodic, JT ;
Feldman, HM .
DEVELOPMENTAL NEUROPSYCHOLOGY, 2000, 18 (02) :139-169
[10]   Local brain functional activity following early deprivation:: A study of postinstitutionalized Romanian orphans [J].
Chugani, HT ;
Behen, ME ;
Muzik, O ;
Juhász, C ;
Nagy, F ;
Chugani, DC .
NEUROIMAGE, 2001, 14 (06) :1290-1301