Intraepidermal Nerve Fibre Density is Decreased in Lesional and Inter-lesional Prurigo Nodularis and Reconstitutes on Healing of Lesions

被引：41

作者：

Bobko, Svetlana ^{[1
]}

Zeidler, Claudia ^{[2
]}

Osada, Nani ^{[3
]}

Riepe, Claudia ^{[2
]}

Pfleiderer, Bettina ^{[4
]}

Pogatzki-Zahn, Esther ^{[5
]}

Lvov, Andrey ^{[1
]}

Staender, Sonja ^{[2
]}

机构：

[1] Moscow Sci & Pract Ctr Dermatovenerol & Cosmetol, Moscow, Russia

[2] Univ Hosp Munster, Ctr Chron Pruritus, Dept Dermatol, Von Esmarch Str 58, DE-48149 Munster, Germany

[3] Univ Hosp Munster, Inst Med Informat, Von Esmarch Str 58, DE-48149 Munster, Germany

[4] Univ Hosp Munster, Dept Clin Radiol, Von Esmarch Str 58, DE-48149 Munster, Germany

[5] Univ Hosp Munster, Dept Anesthesiol Intens Care & Pain Therapy, Von Esmarch Str 58, DE-48149 Munster, Germany

来源：

ACTA DERMATO-VENEREOLOGICA | 2016年 / 96卷 / 03期

关键词：

NEUROPATHY; CRITERIA; SKIN;

D O I：

10.2340/00015555-2232

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Prurigo nodularis (PN) is characterized by the presence of intensely itchy nodules and papules, which are frequently refractory to therapy (1). The results of previous morphological studies indicate that nerve fibres have an important function in PN; in support of this, a dermal neuronal hyperplasia was observed in immunohistochemical studies (2, 3), although this could not be confirmed in histological analysis (4). As intraepidermal nerve fibres have been identified to be of great importance for the sensation of pruritus (5), we investigated them in PN (6). Surprisingly, decreased intraepidermal nerve fibre density (IENFD) independent of clinical parameters was found (6). With this, we hypothesized that reduced nerve fibre density might be due to scratching and, accordingly, that hypoplasia normalizes during healing of PN. To further investigate the role of nerve fibres in PN, we examined the IENFD of PN at different stages. © 2016 The Authors.

引用

页码：404 / 406

页数：3

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