Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitis

被引：41

作者：

Tuzun, Erdern

Rossi, Jeffrey E.

Karner, Steve F.

Centurion, Alejandro F.

Dalmau, Josep

机构：

[1] Hosp Univ Penn, Dept Neurol, Div Neurooncol, Philadelphia, PA 19104 USA

[2] Carolina Neurol Clin, Charlotte, NC USA

[3] Carmel Internal Med & Neurol, Carmel, CA USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 186卷 / 1-2期

关键词：

limbic encephalitis; paraneoplastic; adenylate kinase 5; antibodies;

D O I：

10.1016/j.jneuroim.2007.03.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report two men with limbic encephalitis (LE) refractory to corticosteroids, Wig and plasma exchange. Both patients had serum/CSF antibodies that reacted with the cytoplasm of neurons. Probing of a hippocampal cDNA library resulted in the isolation of adenylate kinase 5 (AK5). Patients' antibodies, but not those of 111 controls, recognized AK5-expressing phage plaques. Human AK5-affinity purified antibodies reproduced the neuronal immunolabeling of patients' antibodies, and co-localized with a rabbit AK5 antibody, confirming that the brain autoantigen was AK5. Detection of antibodies to AK5 in LE patients carries a poor prognosis, and suggests the prompt use of aggressive immunosuppression. (c) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：177 / 180

页数：4

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