A concise route to the highly-functionalized azetidine precursor: the enantioselective synthesis of penaresidin B

被引：14
|
作者：
Ding, Feiqing [1 ]
William, Ronny [1 ]
Kock, Si Min [1 ]
Leow, Min Li [1 ]
Liu, Xue-Wei [1 ]
机构：
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 22期
关键词：
STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; ALKALOIDS; MITSUNOBU;
D O I：
10.1039/c4cc09904d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and high-yielding synthesis of penaresidin B is disclosed herein. The concise 8-step synthesis of azetidine aldehyde was devised by incorporating our novel strategy for ready access to 3-amino-2,3-dideoxysugars via regio- and stereoselective tandem hydroamination/glycosylation of glycal as the key step.
引用
收藏
页码：4639 / 4642
页数：4
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