Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

被引：12

作者：

Bandyopadhyay, Anupam ^{[1
]}

Misra, Rajkumar ^{[1
]}

Gopi, Hosahudya N. ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Pune, Dept Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 27期

关键词：

SECONDARY STRUCTURE; AQUEOUS-SOLUTION; HAIRPIN PEPTIDE; HYBRID PEPTIDE; GAMMA-PEPTIDES; MODEL SYSTEMS; STABILITY; PROTEINS; POLYPEPTIDES; INHIBITORS;

D O I：

10.1039/c6cc00127k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Design, synthesis and single-crystal conformations of hybrid triple-stranded beta-sheets composed of E-vinylogous residues are reported. Restricting conformational flexibility of beta-strands through the insertion of carbon-carbon double bonds at facing positions leads to increased peptide crystallinity, which allowed unambiguous structural characterization of three-stranded beta-sheets. This strategy can be further explored for the design of functional beta-sheets.

引用

收藏

页码：4938 / 4941

页数：4

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