3D quantitative synthetic MRI-derived cortical thickness and subcortical brain volumes: Scan-rescan repeatability and comparison with conventional T1-weighted images

被引：37

作者：

Fujita, Shohei ^{[1
]}

Hagiwara, Akifumi ^{[1
,2
]}

Hori, Masaaki ^{[1
]}

Warntjes, Marcel ^{[3
,4
]}

Kamagata, Koji ^{[1
]}

Fukunaga, Issei ^{[1
]}

Goto, Masami ^{[6
]}

Takuya, Haruyama ^{[1
,5
]}

Takasu, Kohei ^{[6
]}

Andica, Christina ^{[1
]}

Maekawa, Tomoko ^{[1
,2
]}

Takemura, Mariko Yoshida ^{[1
]}

Irie, Ryusuke ^{[1
,2
]}

Wada, Akihiko ^{[1
]}

Suzuki, Michimasa ^{[1
]}

Aoki, Shigeki ^{[1
]}

机构：

[1] Juntendo Univ Hosp, Dept Radiol, Tokyo, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Radiol, Tokyo, Japan

[3] SyntheticMR AB, Linkoping, Sweden

[4] Ctr Med Imaging Sci & Visualizat CMIV, Linkoping, Sweden

[5] Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Dept Radiol Sci, Tokyo, Japan

[6] Kitasato Univ, Sch Allied Hlth Sci, Sagamihara, Kanagawa, Japan

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2019年 / 50卷 / 06期

关键词：

TEST-RETEST RELIABILITY; MULTIPLE-SCLEROSIS; PROTON-DENSITY; CLINICAL FEASIBILITY; ALZHEIMERS-DISEASE; WHITE-MATTER; QUANTIFICATION; SEGMENTATION; RELAXATION; PARCELLATION;

D O I：

10.1002/jmri.26744

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background Previous quantitative synthetic MRI of the brain has been solely performed in 2D. Purpose To evaluate the feasibility of the recently developed sequence 3D-QALAS for brain cortical thickness and volumetric analysis. Study Type Reproducibility/repeatability study. Subjects Twenty-one healthy volunteers (35.6 +/- 13.8 years). Field Strength/Sequence 3D T-1-weighted fast spoiled gradient recalled echo (FSPGR) sequence was performed once, and 3D-QALAS sequence was performed twice with a 3T scanner. Assessment FreeSurfer and FIRST were used to measure cortical thickness and volume of subcortical structures, respectively. Agreement with FSPGR and scan-rescan repeatability were evaluated for 3D-QALAS. Statistical Tests Percent relative difference and intraclass correlation coefficient (ICC) were used to assess reproducibility and scan-rescan repeatability of the 3D-QALAS sequence-derived measurements. Results Percent relative difference compared with FSPGR in cortical thickness of the whole cortex was 3.1%, and 89% of the regional areas showed less than 10% relative difference in cortical thickness. The mean ICC across all regions was 0.65, and 74% of the structures showed substantial to almost perfect agreement. For volumes of subcortical structures, the median percent relative differences were lower than 10% across all subcortical structures, except for the accumbens area, and all structures showed ICCs of substantial to almost perfect agreement. For the scan-rescan test, percent relative difference in cortical thickness of the whole cortex was 2.3%, and 97% of the regional areas showed less than 10% relative difference in cortical thickness. The mean ICC across all regions was 0.73, and 80% showed substantial to almost perfect agreement. For volumes of subcortical structures, relative differences were less than 10% across all subcortical structures except for the accumbens area, and all structures showed ICCs of substantial to almost perfect agreement. Data Conclusion 3D-QALAS could be reliably used for measuring cortical thickness and subcortical volumes in most brain regions. Technical Efficacy: Stage 1

引用

页码：1834 / 1842

页数：9

共 40 条

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