Molecularly endowed hydrogel with an in silico-assisted screened peptide for highly sensitive small molecule harvesting

被引:18
作者
Di Natale, Concetta [1 ]
Celetti, Giorgia [1 ]
Scognamiglio, Pasqualina Liana [1 ]
Cosenza, Chiara [2 ]
Battista, Edmondo [2 ]
Causa, Filippo [1 ,2 ,3 ]
Netti, Paolo A. [1 ,2 ,3 ]
机构
[1] IIT, Ctr Adv Biomat Healthcare, Largo Barsanti & Matteucci 53, I-80125 Naples, Italy
[2] Univ Federico II, Interdisciplinary Res Ctr Biomat CRIB, Piazzale Tecchio 80, I-80125 Naples, Italy
[3] Univ Federico II, DICMAPI, Piazzale Tecchio 80, I-80125 Naples, Italy
关键词
MICROGELS; NANOPARTICLES; AGGREGATION; OCHRATOXIN; CHALLENGES; PROTEINS; APTAMERS; PROBES; FLUIDS;
D O I
10.1039/c8cc04943b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We present a novel method for the detection of small molecules in complex fluids based on the selection of a specific peptide for target capture and its integration into an antifouling polymeric network. Such an approach can represent a universal platform for the direct and ultra-sensitive detection of small molecules in complex media.
引用
收藏
页码:10088 / 10091
页数:4
相关论文
共 36 条
[11]   Supramolecular Spectrally Encoded Microgels with Double Strand Probes for Absolute and Direct miRNA Fluorescence Detection at High Sensitivity [J].
Causa, Filippo ;
Aliberti, Anna ;
Cusano, Angela M. ;
Battista, Edmondo ;
Netti, Paolo A. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (05) :1758-1761
[12]   Functionalized poly(ethylene glycol) diacrylate microgels by microfluidics: In situ peptide encapsulation for in serum selective protein detection [J].
Celetti, Giorgia ;
Di Natale, Concetta ;
Causa, Filippo ;
Battista, Edmondo ;
Netti, Paolo A. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 145 :21-29
[13]   Photocontrollable fluorogenic probes for visualising near-membrane copper(II) in live cells [J].
Chen, Buxiang ;
Wang, Liulin ;
Zhao, Yanfei ;
Ni, Yun ;
Xin, Chenqi ;
Zhang, Chengwu ;
Liu, Jinhua ;
Ge, Jingyan ;
Li, Lin ;
Huang, Wei .
RSC ADVANCES, 2017, 7 (49) :31093-31099
[14]  
Chirinos-Rojas CL, 1998, J IMMUNOL, V161, P5621
[15]   Evolving the use of peptides as components of biomaterials [J].
Collier, Joel H. ;
Segura, Tatiana .
BIOMATERIALS, 2011, 32 (18) :4198-4204
[16]   Cell mechanosensory recognizes ligand compliance at biomaterial interface [J].
Cosenza, Chiara ;
Lettera, Vincenzo ;
Causa, Filippo ;
Scognamiglio, Pasqualina Liana ;
Battista, Edmondo ;
Netti, Paolo Antonio .
BIOMATERIALS, 2016, 76 :282-291
[17]   The reversal by sulfate of the denaturant activity of guanidinium [J].
Dempsey, Christopher E. ;
Mason, Philip E. ;
Bracly, John W. ;
Neilson, George W. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (51) :15895-15902
[18]   An enzyme-linked oligonucleotide assay [J].
Drolet, DW ;
MoonMcDermott, L ;
Romig, TS .
NATURE BIOTECHNOLOGY, 1996, 14 (08) :1021-1025
[19]   Determination of aflatoxin M1 levels in Iranian white and cream cheese [J].
Fallah, Aziz A. ;
Jafari, Tina ;
Fallah, Ali ;
Rahnama, Mohammad .
FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (08) :1872-1875
[20]   Plasmonic Metasurfaces Based on Nanopin-Cavity Resonator for Quantitative Colorimetric Ricin Sensing [J].
Fan, Jiao-Rong ;
Zhu, Jia ;
Wu, Wen-Gang ;
Huang, Yun .
SMALL, 2017, 13 (01)