ObjectivePercutaneous balloon mitral valvuloplasty (PBMV) is the treatment of choice in patients with isolated mitral stenosis. This study aimed to assess the feasibility of PBMV under echocardiography guidance only of isolated mitral stenosis (MS). MethodsFrom October 2016 to Dec 2017, 20 consecutive patients with severe MS underwent PBMV with echocardiography as the only imaging modality at a single center. Outpatient follow-up including chest radiography, electrocardiography, and transthoracic echocardiography was conducted at 1, 3,6, and 12months after the procedure. ResultsAll 20 patients successfully underwent PBMV under echocardiography guidance without radiation and contrast agent. Among them, 2 patients were pregnant, 5 had chronic renal failure, and 1 had history of allergy to contrast. Mitral transvalvular pressure gradient measured at catheterization dropped from 13.352.85mmHg to 5.10 +/- 1.17mmHg (P<.01). Mitral valve area increased from 0.82 +/- 0.10cm(2) pre-PBMV to 1.88 +/- 0.24cm(2) post-PBMV (P<.01). Mean balloon diameter was 26.63 +/- 0.93mm. Mild mitral regurgitation developed in 6 patients. Mean follow-up duration was 6.27 +/- 3.12months. At last follow-up, mitral valve area remained high (1.71 +/- 0.14cm(2)) and mean transmitral pressure gradient low (6.07 +/- 1.03mmHg). No pericardial effusion or peripheral vascular complications occurred. ConclusionIn this small experience, PBMV could be successfully performed under only echocardiography guidance and appeared safe and effective while avoiding radiation and contrast agent use.