Persistent olmesartan-based blood pressure-lowering effects on morning hypertension in Asians: the HONEST study

被引:3
作者
Kario, Kazuomi [1 ]
Saito, Ikuo [2 ]
Kushiro, Toshio [3 ]
Teramukai, Satoshi [4 ]
Yaginuma, Mai [5 ]
Mori, Yoshihiro [5 ]
Okuda, Yasuyuki [5 ]
Kobayashi, Fumiaki [6 ]
Shimada, Kazuyuki [7 ]
机构
[1] Jichi Med Univ, Div Cardiovasc Med, Sch Med, Dept Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan
[2] Keio Univ, Yokohama, Kanagawa 223, Japan
[3] Life Planning Ctr Fdn, Tokyo, Japan
[4] Kyoto Prefectural Univ Med, Dept Biostat, Grad Sch Med Sci, Kyoto, Japan
[5] Daiichi Sankyo, Tokyo, Japan
[6] Daiichi Sankyo Dev, Gerrards Cross, England
[7] Shin Oyama City Hosp, Oyama, Japan
关键词
angiotensin receptor antagonists; Asia; blood pressure monitoring; olmesartan medoxomil; CALCIUM-CHANNEL BLOCKER; CARDIOVASCULAR RISK; COMBINATION THERAPY; HOME; AMLODIPINE; AZELNIDIPINE; SENSITIVITY; POPULATION; MANAGEMENT; PREDICTOR;
D O I
10.1038/hr.2015.148
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Using data from the large-scale HONEST (Home blood pressure measurement with Olmesartan Naive patients to Establish Standard Target blood pressure) study, we investigated the characteristics of the effects of olmesartan-based treatment on morning hypertension in Asian hypertensive patients. Specifically, we investigated the relationship between baseline blood pressure (BP) and BP reduction after 16 weeks by linear regression analyses; determinants of BP reduction were also investigated. For both morning home BP (MHBP) and clinic BP (CBP), reduced systolic BP (SBP) after 16 weeks was associated with baseline SBP (P<0.001). The slope of the regression lines was similar for morning home SBP (MHSBP) (-0.744) and clinic SBP (-0.735). Although sex, concomitant diabetes mellitus and concomitant hepatic disease significantly influence the relationship between BP reduction and baseline BP for MHSBP, none were deemed clinically relevant. In conclusion, olmesartan-based treatment robustly reduced baseline high MHBP, similar to CBP, and the effect was associated with baseline BP but unaffected by patient background factors.
引用
收藏
页码:334 / 341
页数:8
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