Synthesis of ibuprofen loaded magnetic solid lipid nanoparticles

被引：7
作者：
Pang, X. J. [1 ]
Zhou, J.
Chen, J. J.
Yu, M. H.
Cui, F. D.
Zhou, W. L.
机构：
[1] Univ New Orleans, Adv Mat Res Inst, New Orleans, LA 70148 USA
[2] Shenyang Pharmaceut Univ, Coll Pharm, Shenyang 110016, Peoples R China
来源：
IEEE TRANSACTIONS ON MAGNETICS | 2007年 / 43卷 / 06期
基金：
中国国家自然科学基金;
关键词：
magnetic nanoparticles; nanomedicine; solid lipid nanoparticles;
D O I：
10.1109/TMAG.2007.894123
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Ibuprofen loaded magnetic solid lipid nanoparticles (Ib-MSLNs) were successfully fabricated using a two-step method: 1) preparation of a warm O/W microemulsion (aqueous surfactant solution with a lipid phase, containing Ibuprofen, stearic acid, 1-octadecanol and lecithin) in which modified lipophilic magnetite (Fe3O4) nanoparticles were incorporated, and 2) formation of MSLNs by dispersing the warm microemulsion in cold water under mechanical stirring. The Ib-MSLNs were characterized by transmission electron microscopy, X-ray powder diffraction (XRD), and superconducting quantum interference device (SQUID) magnetometer. TEM and XRD results showed that SLN nanoparticles embedded with magnetic nanoparticles was successfully formed. SQUID measurements indicated that Ib-MSLN exhibited superparamagnetic behavior with a blocking temperature of 98 K. The encapsulation efficiency was measured by high pressure liquid chromatography (HPLC). The magnetite-loaded solid lipid nanoparticles can be potentially used in drug targeting and controlled releasing.
引用
收藏
页码：2415 / 2417
页数：3
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